Infecties

Severe Sepsis and Septic Shock

Sepsis is one of the oldest and most elusive syndromes in medicine. Hippocrates claimed that sepsis (σ ´ηψις) was the…

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Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy

Sepsis — severe life-threatening infection with organ dysfunction — initiates a complex interplay of host pro- and anti-inflammatory processes. In…

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The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

Importance Definitions of sepsis and septic shock were last revised in 2001. Considerable advances have since been made into the…

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Invasive Candidiasis

Despite advances in antifungal therapy, the mortality associated with invasive candidiasis remains as high as 40%. This review summarizes recent…

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Approach to invasive pulmonary aspergillosis in critically ill patients

Purpose of review: Apparently immunocompetent critically ill patients represent an increasing population at risk for invasive pulmonary aspergillosis (IPA). The…

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Ventilator-associated pneumonia in the ICU

Ventilator-associated pneumonia (VAP) is defi ned as pneumonia that occurs 48–72 hours or thereafter following endotracheal intubation, characterized by the presence…

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Community-Acquired Pneumonia

Community-acquired pneumonia is a commonly diagnosed illness in which no causative organism is identified in half the cases. Application of…

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Influenza virus-related critical illness: pathophysiology and epidemiology

Influenza virus affects the respiratory tract by direct viral infection or by damage from the immune system response. In humans,…

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Abdominal sepsis

Purpose of reviewTo summarize the recent evidence on the treatment of abdominal sepsis with a specific emphasis on the surgical…

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Necrotizing Soft-Tissue Infections

The hallmarks of necrotizing fasciitis are friable superficial fascia, gray exudate without pus, and widespread tissue destruction. The infection is…

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