Farmacologie

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Pharmacokinetic/pharmacodynamic considerations for the optimization of antimicrobial delivery in the critically ill

Purpose of reviewAntimicrobials are very commonly used drugs in the intensive care setting. Extensive research has been conducted in recent…

Individualised antibiotic dosing for patients who are critically ill: challenges and potential solutions

Infections in critically ill patients are associated with persistently poor clinical outcomes. These patients have severely altered and variable antibiotic…

How do we use therapeutic drug monitoring to improve outcomes from severe infections in critically ill patients?

High mortality and morbidity rates associated with severe infections in the critically ill continue to be a significant issue for…

Continuous versus Intermittent b-Lactam Infusion in Severe Sepsis

Rationale: Optimization of b-lactam antibiotic dosing for critically ill patients is an intervention that may improve outcomes in severe sepsis.…

Beta-Lactam Infusion in Severe Sepsis (BLISS)

a prospective, two-centre, open-labelled randomised controlled trial of continuous versus intermittent beta-lactam infusion in critically ill patients with severe sepsis…

To increase or decrease dosage of antimicrobials in septic patients during continuous renal replacement therapy: the eternal doubt

Critical illness, acute renal failure and continuous renal replacement therapy (CRRT) are associated with changes in pharmacokinetics. Initial antibiotic dose…