Gepost in: Hematologie
HIT is characterized by a platelet-count fall of more than 50% at 5 to 10 days after the start of heparin and hypercoagulability. Platelet factor 4–heparin antibody testing has a high negative, but low positive, predictive value. Treatment involves therapeutic-dose anticoagulation.
Andreas Greinacher, M.D.
N Engl J Med 2015; 373:252-261 DOI: 10.1056/NEJMcp1411910