Intensivist

Venous thromboembolism in the ICU: main characteristics, diagnosis and thromboprophylaxis

Venous thromboembolism (VTE), including pulmonary embolism (PE) and deep venous thrombosis (DVT), is a common and severe complication of critical…

Blood Product Administration in the Critical Care and Perioperative Settings

Anemia and blood transfusion in the critically ill patient with cardiovascular disease

BackgroundAnemia and cardiovascular disease Approximately seven million people in the United Kingdom, and 30% of patients admitted to the ICU…

Transfusion-related acute lung injury: a clinical review

Three decades ago, transfusion-related acute lung injury (TRALI) was considered a rare complication of transfusion medicine. Nowadays, the US Food…

Guidelines on the management of anaemia and red celltransfusion in adult critically ill patients

This document aims to summarize the current literatureguiding the use of red cell transfusion in critically ill patientsand provides recommendations…

The European guideline on management of major bleeding and coagulopathy following trauma: fourth edition

BackgroundSevere trauma continues to represent a global public health issue and mortality and morbidity in trauma patients remains substantial. A…

Acute Myeloid Leukemia

Many recent biologic insights have shed light on the nosology of acute myeloid leukemia. Although this new knowledge has not…

How I treat hyperleukocytosis in acute myeloid leukemia

Hyperleukocytosis (HL) per se is a laboratory abnormality, commonly defined by a white blood cell count >100 000/µL, caused by leukemic…

Hematopoietic Stem-Cell Transplantation

Hematopoietic stem-cell transplantation, which is used to treat both malignant and nonmalignant conditions, was first conceived more than 50 years…

The Tumor Lysis Syndrome

The tumor lysis syndrome is the most common disease-related emergency in children and adults with hematologic cancers. This review summarizes…