Gepost in: Nefrologie
Acute kidney injury due to rhabdomyolysis and renal replacement therapy: a critical review
Rhabdomyolysis, a clinical syndrome caused by damage to skeletal muscle and release of its
breakdown products into the circulation, can be followed by acute kidney injury (AKI) as a severe complication. The belief that the AKI is triggered by myoglobin as the toxin responsible appears to be oversimplified. Better knowledge of the pathophysiology of rhabdomyolysis and following AKI could widen treatment options, leading to preservation of the kidney: the decision to initiate renal replacement therapy in clinical practice should not be made on the basis of the myoglobin or creatine phosphokinase serum concentrations.
Nadezda Petejova and Arnost Martinek
Critical Care 2014 2014, 18:224